Individualized gray matter morphological abnormalities unveil two neuroanatomical obsessive-compulsive disorder subtypes.

ABSTRACT: Obsessive-compulsive disorder (OCD) is a highly heterogeneous disorder, with notable variations among cases in structural brain abnormalities. To address this heterogeneity, our study aimed to delineate OCD subtypes based on individualized gray matter morphological differences. We recruited 100 untreated, first-episode OCD patients and 106 healthy controls for structural imaging scans. Utilizing normative models of gray matter volume, we identified subtypes based on individual morphological abnormalities. Sensitivity analyses were conducted to validate the reproducibility of clustering outcomes. To gain deeper insights into the connectomic and molecular underpinnings of structural brain abnormalities in the identified subtypes, we investigated their associations with normal brain network a

SUBMITTER: Wen B 

PROVIDER: S-EPMC11760359 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature