Investigation of the osteogenic effects of ICA and ICSII on rat bone marrow mesenchymal stem cells.

ABSTRACT: Icariin (ICA) serves as the primary biologically active compound in traditional Chinese medicine Epimedium, while Icariside II (ICSII) represents one of its gastrointestinal metabolites. Although ICA and ICSII have demonstrated osteogenic differentiation- promoting effects on BMSCs, there is limited literature comparing their effects and underlying mechanisms. This study aimed to compare the osteogenic effects of Icariin and Icariside II, along with their respective osteogenic mechanisms. In this study, we initially determined the optimal concentrations of Icariin (10^-5 mol/L) and Icariside II (10^-6 mol/L) for inducing rBMSCs osteogenic differentiation using CCK8, ALP activity assay, and flow apoptosis assay. Subsequently, we compared the vascularization and osteogeni

SUBMITTER: Yao Z 

PROVIDER: S-EPMC11760372 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature