Integrated analysis of protein sequence and structure redefines viral diversity and the taxonomy of the <i>Flaviviridae</i>.

ABSTRACT: The Flaviviridae are a family of non-segmented positive-sense enveloped RNA viruses containing significant pathogens including hepatitis C virus and yellow fever virus. Recent large-scale metagenomic surveys have identified many diverse RNA viruses related to classical orthoflaviviruses and pestiviruses but quite different genome lengths and configurations, and with a hugely expanded host range that spans multiple animal phyla, including molluscs, cnidarians and stramenopiles,, and plants. Grouping of RNA-directed RNA polymerase (RdRP) hallmark gene sequences of flavivirus and 'flavi-like' viruses into four divergent clades and multiple lineages within them was congruent with helicase gene phylogeny, PPHMM profile comparisons, and comparison of RdRP protein structure predicted by Al

SUBMITTER: Simmonds P 

PROVIDER: S-EPMC11760431 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature