Unusual presentation and management of parathyroid carcinoma with pulmonary metastasis: a case report.

ABSTRACT:

Background

Parathyroid carcinoma is a rare and challenging malignancy, often confirmed by histopathological analysis. Due to its rarity, it can present in atypically. We present a case of parathyroid carcinoma with an unusual course of pulmonary metastasis emphasizing the complexities of its diagnosis and management.

Case description

A 38-year-old lady was referred to our department when her newborn was found to have hypoparathyroidism. Laboratory tests showed elevated parathyroid hormone (PTH) and adjusted calcium levels. Imaging studies suggested the presence of parathyroid tumors, and histopathology confirmed parathyroid carcinoma. Immunohistochemistry was positive for GATA3 in the tumor cells, and next generation sequencing revealed CDC73 mutation, MYC rearrangement, ASX

SUBMITTER: Alrabiah HF 

PROVIDER: S-EPMC11760510 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature