A systematic review on malaria and Tuberculosis (TB) vaccine challenges in sub-Saharan African clinical trials.

ABSTRACT:

Objective

For more than a century, developing novel and effective vaccines against malaria and Tuberculosis (TB) infections has been a challenge. This review sought to investigate the reasons for the slow progress of malaria and TB vaccine candidates in sub-Saharan African clinical trials.

Methods

The systematic review protocol was registered on PROSPERO on July 26, 2023 (CRD42023445166). The research articles related to the immunogenicity, efficacy, or safety of malaria or TB vaccines that were published between January 1, 2012, and August 31, 2023, were searched on three databases: Web of Science (WoS), PubMed, and ClinicalTrials.gov.

Results

A total of 2342 articles were obtained, 50 of which met the inclusion criteria. 28 (56%) articles reported on malaria vaccine

SUBMITTER: Hamisi MA 

PROVIDER: S-EPMC11760592 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature