Geographical variation in metabolite profiles and bioactivity of <i>Thesium chinense</i> Turcz. revealed by UPLC-Q-TOF-MS-based metabolomics.

ABSTRACT:

Introduction

This study aims to investigate the impact of geographical origin on the metabolite composition and bioactivity of Thesium chinense Turcz. (TCT), a member of the Apiaceae family renowned for its wide range of pharmacological properties, including antioxidant, antimicrobial, and anti-inflammatory effects. In this study, we investigated the whole plants of TCT from different regions in China, aiming to explore the geographical variation of TCT.

Methods

A non-targeted metabolomics approach was employed using ultra-high-performance liquid chromatography combined with quadrupole time-of-flight mass spectrometry (UPLC-Q-TOF-MS). Principal component analysis (PCA) and partial least squares discriminant analysis (PLS-DA) were utilized to identify and differentiate the me

SUBMITTER: Zhang F 

PROVIDER: S-EPMC11760594 | biostudies-literature | 2024

REPOSITORIES: biostudies-literature