Novel inflammatory markers in intracerebral hemorrhage: Results from Olink proteomics analysis.

ABSTRACT: Inflammation is a crucial factor in intracerebral hemorrhage (ICH) pathophysiology, but specific inflammatory biomarkers in ICH patients remain unclear. This study aimed to identify novel circulating inflammatory biomarkers for improved ICH prediction and diagnosis. We profiled expression levels of 92 cardiovascular disease related proteins in plasma from 26 matched ICH patients and controls using Olink technology. Differentially expressed proteins were validated using ELISA and RT-qPCR in a second matched cohort. Receiver operating characteristic (ROC) curves evaluated how well the diagnostic tests performed. The study identified 18 inflammatory-related proteins with significantly different expression levels between ICH patients and controls. These proteins participate in critical biologi

SUBMITTER: Hu Z 

PROVIDER: S-EPMC11760662 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature