Natural Killer Cell Education in Women With Recurrent Pregnancy Loss.

ABSTRACT:

Problem

Natural killer (NK) cells undergo education for full functionality via interactions between killer immunoglobulin-like receptors (KIRs) or NKG2A and human leukocyte antigen (HLA) ligands. Presumably, education is important during early pregnancy as insufficient education has been associated with impaired vascular remodeling and restricted fetal growth in mice. NK cell education is influenced by receptor co-expression patterns, human cytomegalovirus (CMV), the HLA-E^R107^G dimorphism, and HLA-B leader peptide variants. We hypothesized altered NK cell education status and differences in frequencies of HLA-E genotypes and HLA-B leader peptide variants in women with recurrent pregnancy loss (RPL) compared to women with previously uncomplicated pregnancies, a

SUBMITTER: Lombardi AEM 

PROVIDER: S-EPMC11760664 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature