Increased aqueous humor levels of endothelin-1 in patients with open angle glaucoma.

ABSTRACT:

Background

Endothelin is a potent vasoconstrictor and contributes to the regulation of vascular perfusion. Aberrant endothelin-1 (ET-1) levels in aqueous humor have been reported across a variety of vascular diseases of the eye, including glaucoma. These findings suggest that dysregulation of ET-1 production may contribute to glaucoma pathophysiology. In this study, aqueous humor from patients undergoing ocular surgery was assayed for ET-1 abundance and related to the presence of glaucoma.

Patients

Open angle glaucoma patients (n=62 total) from the ophthalmology clinics of the University of Iowa Hospitals and Clinics were enrolled in this study and organized into three distinct cohorts based on their diagnostic criteria, including those with primary open angle glaucoma (POAG

SUBMITTER: Hedberg-Buenz A 

PROVIDER: S-EPMC11760677 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature