Community assembly modeling of microbial evolution within Barrett's esophagus and esophageal adenocarcinoma.

ABSTRACT: Mathematical modeling of somatic evolution, a process impacting both host cells and microbial communities in the human body, can capture important dynamics driving carcinogenesis. Here we considered models for esophageal adenocarcinoma (EAC), a cancer that has dramatically increased in incidence over the past few decades in Western populations, with high case fatality rates due to late-stage diagnoses. Despite advancements in genomic analyses of the precursor Barrett's esophagus (BE), prevention of late-stage EAC remains a significant clinical challenge. Previous microbiome studies in BE and EAC have focused on quantifying static microbial abundance differences rather than evolutionary dynamics. Using whole genome sequencing data from esophageal tissues, we first applied a robust bioinform

SUBMITTER: Guccione C 

PROVIDER: S-EPMC11760701 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature