Comparative analysis of Xenopus mesonephric transcriptomics: Conservation of the developmental lineage of nephron stages.

ABSTRACT: The mammalian kidney develops in three sequential stages referred to as the pronephros, mesonephros, and metanephros, each developing from the preceding form. All three phases of kidney development utilize epithelized tubules called nephrons, which function to take in filtrate from the blood or coelom and selectively reabsorb solutes the organism needs, leaving waste products to be excreted as urine. The pronephros are heavily studied in aquatic organisms such as zebrafish and Xenopus, as they develop quickly and are functional. The metanephros is a preferred mammalian kidney model, as it best recapitulates human disease. However, very little is known about the mesonephric stage of kidney development in any organism. The pronephros extend to form the mesonephric duct, which ultimately deve

SUBMITTER: Corkins ME 

PROVIDER: S-EPMC11760729 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature