From macro to micro: De novo genomes of Aedes mosquitoes enable comparative genomics among close and distant relatives.

ABSTRACT: The yellow fever mosquito (Aedes aegypti) is an organism of high medical importance because it is the primary vector for diseases such as yellow fever, Zika, dengue, and chikungunya. Its medical importance has made it a subject of numerous efforts to understand their biology. One such effort, was the development of a high-quality reference genome (AaegL5). However, this reference genome was sourced from a highly inbred laboratory strain with unknown geographic origin. Thus, the reference is not representative of a wild mosquito, let alone one from its native range in sub-Saharan Africa. To better understand the genetic architecture of Ae. aegypti and their sister species, we developed two de novo chromosome-scale genomes with sequences sourced from single individuals:

SUBMITTER: Morinaga G 

PROVIDER: S-EPMC11760778 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature