Hospital toilets and drainage systems as a reservoir for a long-term polyclonal outbreak of clinical infections with multidrug-resistant Klebsiella oxytoca species complex.

ABSTRACT:

Background

Nosocomial outbreaks with multidrug-resistant bacteria with a probable reservoir in hospital toilets and drainage systems have been increasingly reported.

Aim

To investigate an increase in bacteraemia with extended-spectrum β-lactamase (ESBL)-producing Klebsiella oxytoca at our hospital in 2021; the epidemiology of the outbreak suggested an environmental source.

Methods

Available clinical K. oxytoca isolates from patient with infection or rectal carriage from 2019 to 2022 were collected. Clinical information was gathered from included patients and sampled sinks, shower drains, and toilet water. Short- and long-read whole-genome sequencing (WGS) was performed on patient and environmental isolates to assess phylogenetic relationships, antibiotic

SUBMITTER: Larsen AL 

PROVIDER: S-EPMC11760810 | biostudies-literature | 2025 Mar

REPOSITORIES: biostudies-literature