The Effects of Synthetic Polymers on the Release Patterns of Bupivacaine Hydrochloride from Sodium Hyaluronate Hydrogels.

ABSTRACT:

Background

Using hydrogels for the controlled release of drugs is beneficial for patients, who then receive the proper dose of the medicinal substance. In addition, the formulation can provide more consistent drug absorption while reducing the frequency of dosing.

Objectives

The aim of this investigation is to propose a novel HA (sodium hyaluronate)-based hydrogel for intra-articular injection doped with synthetic polymers and incorporated with bupivacaine hydrochloride (Bu) as a local anesthetic. The other aim of this study is to reveal the effects of the formulation's ingredients on its viscosity and the relationship between the hydrogel's viscosity and drug release.

Methods

First, HA-based hydrogels doped with synthetic polymers and incorporated with Bu were prepar

SUBMITTER: Wojcik-Pastuszka D 

PROVIDER: S-EPMC11760862 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature