Estimating realized relatedness in free-ranging macaques by inferring identity-by-descent segments.

ABSTRACT: Biological relatedness is a key consideration in studies of behavior, population structure, and trait evolution. Except for parent-offspring dyads, pedigrees capture relatedness imperfectly. The number and length of identical-by-descent DNA segments (IBD) yield the most precise relatedness estimates. Here, we leverage different methods for estimating IBD segments from low-depth whole genome resequencing data to demonstrate the feasibility and value of resolving fine-scaled gradients of relatedness in free-living animals. Using primarily 4 to 6× depth data from a rhesus macaque (Macaca mulatta) population with long-term pedigree data, we show that we can infer the number and length of IBD segments across the genome with high accuracy even at 0.5× sequencing depth. In line with expect

SUBMITTER: Freudiger A 

PROVIDER: S-EPMC11760927 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature