Specialization of the human hippocampal long axis revisited.

ABSTRACT: The hippocampus possesses anatomical differences along its long axis. Here, we explored the functional specialization of the human hippocampal long axis using network-anchored precision functional MRI in two independent datasets (N = 11 and N = 9) paired with behavioral analysis (N = 266 and N = 238). Functional connectivity analyses demonstrated that the anterior hippocampus was preferentially correlated with a cerebral network associated with remembering, while the posterior hippocampus selectively contained a region correlated with a distinct network associated with behavioral salience. Seed regions placed within the hippocampus recapitulated the distinct cerebral networks. Functional characterization of the anterior and posterior hippocampal regions using task data identified and repli

SUBMITTER: Angeli PA 

PROVIDER: S-EPMC11760929 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature