Genomic clustering tendency of transcription factors reflects phase-separated transcriptional condensates at super-enhancers.

ABSTRACT: Many transcription factors (TFs) have been shown to bind to super-enhancers, forming transcriptional condensates to activate transcription in various cellular systems. However, the genomic and epigenomic determinants of phase-separated transcriptional condensate formation remain poorly understood. Questions regarding which TFs tend to associate with transcriptional condensates and what factors influence their association are largely unanswered. Here we systematically analyzed 571 DNA sequence motifs across the human genome and 6650 TF binding profiles across different cell types to identify the molecular features contributing to the formation of transcriptional condensates. We found that the genomic distributions of sequence motifs for different TFs exhibit distinct clustering tendencies.

SUBMITTER: Wang S 

PROVIDER: S-EPMC11760973 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature