Health outcomes in chronic kidney disease patients with cognitive impairment or dementia: a global collaborative analysis.

ABSTRACT:

Background and hypothesis

Mild cognitive impairment and dementia (CI) are common in patients with CKD. We aim to clarify whether and how CKD and CI coexistence increases adverse health outcomes.

Methods

This retrospective observational cohort study was conducted on CKD patients (stages 3-5) from the TriNetX platform. CKD patients with and without pre-existing CI were included from 115 healthcare organizations, and their outcomes were compared. The two cohorts were propensity score matched (PSM) for age, sex, ethnicity, comorbidities, BMI, blood parameters, and medications. The proportional hazard assumption was tested with a 95% confidence interval. Kaplan-Meier analysis was used to calculate survival probability. Outcomes were included from 1 day after the CKD diagnosis unt

SUBMITTER: Merlino L 

PROVIDER: S-EPMC11761004 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature