Experience-dependent reorganization of inhibitory neuron synaptic connectivity.

ABSTRACT: Organisms continually tune their perceptual systems to the features they encounter in their environment^1-3. We have studied how ongoing experience reorganizes the synaptic connectivity of neurons in the olfactory (piriform) cortex of the mouse. We developed an approach to measure synaptic connectivity in vivo, training a deep convolutional network to reliably identify monosynaptic connections from the spike-time cross-correlograms of 4.4 million single-unit pairs. This revealed that excitatory piriform neurons with similar odor tuning are more likely to be connected. We asked whether experience enhances this like-to-like connectivity but found that it was unaffected by odor exposure. Experience did, however, alter the logic of interneuron connectivity. Following repeated

SUBMITTER: Fink AJP 

PROVIDER: S-EPMC11761011 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature