Chloramphenicol-mobilized <i>Bacillus subtilis</i> transiently expresses resistance to multiple antibiotics, including the glycopeptides phleomycin and bleomycin.

ABSTRACT: Antibiotic resistance is a global crisis that stems from the use of antibiotics as an essential part of modern medicine. Understanding how antibiotic resistance is controlled among cells in bacterial populations will provide insights into how antibiotics shape microbial communities. Here, we describe patterns of B. subtilis gene expression that arise from growth on a surface either in isolation or under subinhibitory chloramphenicol exposure. We identified elevated expression of genes encoding five different antibiotic resistance functions. The expression of four of the five resistance functions is controlled by a combination of terminator attenuation and transcriptional regulation. Two of these, vmlR and tlrB provide resistance to lincosamides and tylosin, respectivel

SUBMITTER: LaBonte S 

PROVIDER: S-EPMC11761127 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature