Unraveling the transcriptomic effects of leucine supplementation on muscle growth and performance in basketball athletes.

ABSTRACT: Leucine has gained recognition as an athletic dietary supplement in recent years due to its various benefits; however, the underlying molecular mechanisms remain unclear. In this study, 20 basketball players were recruited and randomly assigned to two groups. Baseline exercise performance-assessed through a 282-foot sprint, free throws, three-point field goals, and self-rated practice assessments-was measured prior to leucine supplementation. Participants were then given a functional drink containing either leucine (50 mg/kg body weight) or a placebo for 28 days. After supplementation, the same exercise performance metrics were reassessed. Following leucine supplementation, biceps brachii muscle tissue from both groups was collected for transcriptome sequencing and qPCR verification. Our r

SUBMITTER: Wang S 

PROVIDER: S-EPMC11761164 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature