Antibiotic exposure is associated with minimal gut microbiome perturbations in healthy term infants.

ABSTRACT:

Background

The evolving infant gut microbiome influences host immune development and later health outcomes. Early antibiotic exposure could impact microbiome development and contribute to poor outcomes. Here, we use a prospective longitudinal birth cohort of n = 323 healthy term African American children to determine the association between antibiotic exposure and the gut microbiome through shotgun metagenomics sequencing as well as bile acid profiles through liquid chromatography-mass spectrometry.

Results

Stool samples were collected at ages 4, 12, and 24 months for antibiotic-exposed (n = 170) and unexposed (n = 153) participants. A short-term substudy (n = 39) collected stool samples at first exposure, and over 3 weeks following antibiotics initiation. Antibiotic exposur

SUBMITTER: Benitez AJ 

PROVIDER: S-EPMC11761179 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature