GPR137-RAB8A activation promotes ovarian cancer development via the Hedgehog pathway.

ABSTRACT:

Background

Ovarian cancer (OC) progression is one of the commonest cause of female cancer death. While treatments in clinic includes primary surgery and targeted chemotherapy, curative and survival trends in OC have not significantly improved. Thus, further investigation of the mechanisms regarding OC carcinogenesis and discovery of novel targets is of great importance.

Methods

Human ovarian tissue specimens, RNA sequencing, GEPIA database and bioinformatics analyses were used to analyze the gene correlation, and to identify and validate potential downstream candidates. The biological effects of GPR137-RAB8A-Hedgehog(HH) were investigated using in vitro and in vivo models and methods including qRT-PCR, RNA stability assay, RNA immunoprecipitation assay, GLI-luciferase report

SUBMITTER: Tang C 

PROVIDER: S-EPMC11761205 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature