Evaluating the risk of mild serotonin syndrome in primary care: a retrospective case series of patients with treatment-resistant depression.

ABSTRACT:

Background

Serotonin syndrome is an adverse drug reaction characterised by the excess of serotonin activity in the central nervous system. It is a condition of great concern in primary care where some patients, usually with treatment-resistant depression, get treatment with multiple serotonergic agents.

Case description

This retrospective case series looked at 20 primary care patients with treatment-resistant depression who developed mild serotonin syndrome after starting a second antidepressant. The patients were, on average, 40.4 years old, with 55% being female, and had been in treatment for about 5.3 years. The study also considered other health conditions and medications the patients were using. Interventions included stopping or reducing the dose of the second antidepr

SUBMITTER: Jerjes W 

PROVIDER: S-EPMC11761319 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature