Sex differences and determinants of coronary microvascular function in asymptomatic adults with type 2 diabetes.

ABSTRACT:

Background

Coronary microvascular dysfunction (CMD) is a significant complication in type 2 diabetes (T2D) and may be more common in women. We aimed to evaluate the sex differences and sex-specific clinical determinants of CMD in adults with T2D without prevalent cardiovascular disease.

Methods

Single center pooled analysis of four prospective studies comparing asymptomatic people with T2D and controls. All subjects underwent comprehensive cardiovascular phenotyping with myocardial perfusion reserve (MPR) quantified with perfusion cardiovascular magnetic resonance (CMR). Participants with silent coronary disease were excluded. Multivariable linear regression was performed to identify determinants of MPR with an interaction term for sex.

Results

Four hundred and sevent

SUBMITTER: Yeo JL 

PROVIDER: S-EPMC11761338 | biostudies-literature | 2025 Summer

REPOSITORIES: biostudies-literature