Patterns of population structure and genetic variation within the Saudi Arabian population.

ABSTRACT: The Arabian Peninsula is considered the initial site of historic human migration out of Africa. The modern-day indigenous Arabians are believed to be the descendants who remained from the ancient split of the migrants into Eurasia. Here, we investigated how the population history and cultural practices such as endogamy have shaped the genetic variation of the Saudi Arabians. We genotyped 3,352 individuals and identified twelve genetic sub-clusters that corresponded to the geographical distribution of different tribal regions, differentiated by distinct components of ancestry based on comparisons to modern and ancient DNA references. These sub-clusters also showed variation across ranges of the genome covered in runs of homozygosity, as well as differences in population size changes over ti

SUBMITTER: Malomane DK 

PROVIDER: S-EPMC11761371 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature