Distinct CD8⁺ T-cell types Associated with COVID-19 Severity in Unvaccinated HLA-A2⁺ Patients.

ABSTRACT: Although emerging data have revealed the critical role of memory CD8⁺ T cells in preventing and controlling SARS-CoV-2 infection, virus-specific CD8⁺ T-cell responses against SARS-CoV-2 and its memory and innate-like subsets in unvaccinated COVID-19 patients with various disease manifestations in an HLA-restricted fashion remain to be understood. Here, we show the strong association of protective cellular immunity with mild COVID-19 and unique cell types against SARS-CoV-2 virus in an HLA-A2 restricted manner. ELISpot assays reveal that SARS-CoV-2-specific CD8⁺ T-cell responses in mild COVID-19 patients are significantly higher than in severe patients, whereas neutralizing antibody responses against SARS-CoV-2 virus significantly correlate with disease seve

SUBMITTER: Masuda K 

PROVIDER: S-EPMC11761488 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature