Lower slow wave sleep and rapid eye-movement sleep are associated with brain atrophy of AD-vulnerable regions.

ABSTRACT:

Study objectives

Sleep deficiency is associated with Alzheimer's disease (AD) pathogenesis. We examined the association of sleep architecture with anatomical features observed in AD: (1) atrophy of hippocampus, entorhinal, inferior parietal, parahippocampal, precuneus, and cuneus regions ("AD-vulnerable regions") and (2) cerebral microbleeds.

Methods

In 271 participants of the Atherosclerosis Risk in the Communities Study, we examined the association of baseline sleep architecture with anatomical features identified on brain MRI 13~17 years later. Sleep architecture was quantified as the proportion of slow wave sleep (SWS), proportion of rapid eye-movement sleep (REM), and arousals index using polysomnography. Outcomes included (1) volumetric measurements of each AD-vulnerab

SUBMITTER: Cho G 

PROVIDER: S-EPMC11761512 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature