Atlas of plasma metabolic markers linked to human brain morphology.

ABSTRACT:

Background

Metabolic processes form the basis of the development, functioning and maintenance of the brain. Despite accumulating evidence of the vital role of metabolism in brain health, no study to date has comprehensively investigated the link between circulating markers of metabolic activity and in vivo brain morphology in the general population.

Methods

We performed uni- and multivariate regression on metabolomics and MRI data from 24,940 UK Biobank participants, to estimate the individual and combined associations of 249 circulating metabolic markers with 91 measures of global and regional cortical thickness, surface area and subcortical volume. We investigated similarity of the identified spatial patterns with brain maps of neurotransmitters, and used Mendelian

SUBMITTER: van der Meer D 

PROVIDER: S-EPMC11761619 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature