Olivetol's Effects on Metabolic State and Gut Microbiota Functionality in Mouse Models of Alimentary Obesity, Diabetes Mellitus Type 1 and 2, and Hypercholesterolemia.

ABSTRACT:

Background

Disorders of glucose and lipid metabolism, such as obesity, diabetes mellitus, or hypercholesterolemia, can cause serious complications, reduce quality of life, and lead to increased premature mortality. Olivetol, a natural compound, could be proposed as a promising therapeutic agent for preventing, treating, or alleviating metabolic complications of such pathological conditions.

Methods

In this study, the researchers conducted a broad parallel investigation of olivetol's effects on metabolic state and gut microbiota functionality in mouse models of alimentary obesity, diabetes mellitus type 1 and 2, and hypercholesterolemia.

Results

According to the results of the study, olivetol caused a lowering of body weight in C57Bl6 mice fed a high-fat diet and in

SUBMITTER: Zabolotneva AA 

PROVIDER: S-EPMC11761620 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature