Category-biased patches encircle core domain-general regions in the human lateral prefrontal cortex.

ABSTRACT: The fine-grained functional organization of the human lateral prefrontal cortex (PFC) remains poorly understood. Previous fMRI studies delineated focal domain-general, or multiple-demand (MD), PFC areas that co-activate during diverse cognitively demanding tasks. While there is some evidence for category-selective (face and scene) patches, in human and non-human primate PFC, these have not been systematically assessed. Recent precision fMRI studies have also revealed sensory-biased PFC patches adjacent to MD regions. To investigate if this topographic arrangement extends to other domains, we analysed two independent fMRI datasets (n=449 and n=37) utilizing the high-resolution multimodal MRI approaches of the Human Connectome Project (HCP). Both datasets included cognitive control tasks and

SUBMITTER: Assem M 

PROVIDER: S-EPMC11761636 | biostudies-literature | 2025 May

REPOSITORIES: biostudies-literature