Diversification and recurrent adaptation of the synaptonemal complex in Drosophila.

ABSTRACT: The synaptonemal complex (SC) is a protein-rich structure essential for meiotic recombination and faithful chromosome segregation. Acting like a zipper to paired homologous chromosomes during early prophase I, the complex is a symmetrical structure where central elements are connected on two sides by the transverse filaments to the chromatin-anchoring lateral elements. Despite being found in most major eukaryotic taxa implying a deeply conserved evolutionary origin, several components of the complex exhibit unusually high rates of sequence turnover. This is puzzlingly exemplified by the SC of Drosophila, where the central elements and transverse filaments display no identifiable homologs outside of the genus. Here, we exhaustively examine the evolutionary history of the SC in Drosophila ta

SUBMITTER: Zakerzade R 

PROVIDER: S-EPMC11761671 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature