A genealogy-based approach for revealing ancestry-specific structures in admixed populations.

ABSTRACT: Elucidating ancestry-specific structures in admixed populations is crucial for comprehending population history and mitigating confounding effects in genome-wide association studies. Existing methods for elucidating the ancestry-specific structures generally rely on frequency-based estimates of genetic relationship matrix (GRM) among admixed individuals after masking segments from ancestry components not being targeted for investigation. However, these approaches disregard linkage information between markers, potentially limiting their resolution in revealing structure within an ancestry component. We introduce ancestry-specific expected GRM (as-eGRM), a novel framework for elucidating the relatedness within ancestry components between admixed individuals. The key design of as-eGRM consist

SUBMITTER: Tang J 

PROVIDER: S-EPMC11761683 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature