Exploring the therapeutic effect of human recombinant IL11 on lesioned OA human osteochondral explants.

ABSTRACT:

Objective

To explore IL11 co-expression profiles in our previously reported RNA-sequencing dataset of OA articular cartilage, in interaction with IL6, and to investigate the effects of hrIL11 administration as potential therapeutic strategy for OA articular cartilage using our biomimetic aged human osteochondral explant model of OA.

Methods

We used RNA-sequencing datasets of macroscopically preserved and lesioned OA articular cartilage (N = 35 patients). Spearman correlations were calculated between IL11 and IL6 expression levels and genes expressed in cartilage (N = 20048 genes). Osteochondral explants were isolated from macroscopically preserved and lesioned areas of the joint and were kept in culture for two weeks, with or without exposure to 200ng/ml hrIL11.

Results</

SUBMITTER: Tuerlings M 

PROVIDER: S-EPMC11761764 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature