Prevalence and natural development of thoracolumbar kyphosis in achondroplasia: A systematic review and meta-analysis.

ABSTRACT:

Introduction

Thoracolumbar kyphosis (TLK) is a frequently reported spinal deformity in achondroplasia, which in combination with the characteristic narrow spinal canal in achondroplasia predisposes for symptomatic spinal stenosis. There is however no consensus on the optimal treatment, due to limited data on diagnostic criteria, the natural development and the prevalence of TLK.

Research question

This study aims to assess the prevalence, natural development, and diagnostic criteria for pathological TLK in individuals with achondroplasia.

Material and methods

A systematic review and meta-analysis were conducted. Studies involving achondroplasia patients, which reported TLK measurement methods were included. The primary outcome was the pooled prevalence of TLK, stratifi

SUBMITTER: Omara C 

PROVIDER: S-EPMC11761886 | biostudies-literature | 2025

REPOSITORIES: biostudies-literature