Secreted extracellular heat shock protein gp96 and inflammatory cytokines are markers of severe malaria outcome.

ABSTRACT: Malaria caused by Plasmodium spp., is a major public health issue in sub-Saharan Africa. The fight against malaria has stalled due to increasing resistance to treatments and insecticides. There is an urgent need to focus on new therapeutic targets to combat malaria effectively. This study aimed to measure the secreted heat shock protein gp96 levels in both malaria patients and controls. Indeed, gp96 plays a crucial role in parasite survival within the host and in establishing a successful infection. Therefore, gp96 could be a promising target for antimalarial drugs. In our study, we included 60 malaria patients, 30 with severe malaria (SM) and 30 with uncomplicated malaria (UM). Additionally, 28 controls were included. Using the ELISA method, we measured gp96 levels in the participants' bl

SUBMITTER: Thiam F 

PROVIDER: S-EPMC11761890 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature