Characterization and comparative transcriptomic analysis of high-altitude adaptation in Tibetan chicken using RNA-sequencing.

ABSTRACT: Tibetan chicken, an indigenous breed, inhabit highland regions and are crucial livestock for local Tibetans. Compared with other chicken breeds that have migrated from lowlands to highlands, Tibetan chicken exhibits superior physiological adaptations to high-altitude environments. However, the genetic mechanisms underlying these adaptations remain unclear. Herein, we generated high-quality RNA-sequencing data from the heart samples of 19 adult lowland and Tibetan chickens subjected to hypoxic and normoxic conditions for 5 weeks. We explored the relationships between chicken populations and the environment using different expression gene detection and weighted gene co-expression network analysis (WGCNA). The Tibetan chicken genome was analyzed for positive selection pressures associated wit

SUBMITTER: Zhong H 

PROVIDER: S-EPMC11761939 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature