Approaches of Inducing Tolerance to Murine Schistosomiasis mansoni applying Biomphalaria and Bulinus Proteins.

ABSTRACT:

Background

The freshwater snails Biomphalaria alexandrina and Bulinus trancatus are key contributors to the transmission of S. mansoni and S.haematobium, respectively, for being their intermediate hosts.

Objectives

This research study aimed to investigate the potency of the nucleoproteins (NPs) extracted from both snail species on the host immune reactions as an approach to developing a potential vaccine.

Methods

Three groups of six-week-old Swiss-Webster mice (n = 18; 15-20 g each) were injected intraperitoneally for three consecutive weeks with single doses (once a week) of B. alexandrina, B. truncatus, or a mixture of their nucleoproteins (50 µg each). On day 21st, the nucleoprotein-treated mice altogether, with six more mice, received subcutaneously S. mansoni cer

SUBMITTER: Mossalem HS 

PROVIDER: S-EPMC11761983 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature