Giardia fibrillarin: a bioinformatics exploration of sequence and structure.

ABSTRACT: Fibrillarin is a key nucleolar S-adenosyl-L-methionine (SAM)-dependent methyltransferase, highly conserved among species in both sequence and function. It is actively involved in numerous cellular processes, particularly in the early stages of pre-ribosomal RNA processing. Although a fibrillarin orthologue has been identified in Giardia, an intestinal protozoan parasite responsible for numerous infections worldwide, its functional and structural features in this parasite remain largely unexplored. In this study, bioinformatics tools were used to analyze the sequence and structure of Giardia fibrillarin to provide insights that could aid future experimental and therapeutic investigations. Taking advantage of the protein sequence of Giardia fibrillarin, multiple bioinformatics tools were emp

SUBMITTER: Lagunas-Rangel FA 

PROVIDER: S-EPMC11761994 | biostudies-literature | 2025 Feb

REPOSITORIES: biostudies-literature