Dose-dependent association of hyperoxia and decreased favorable outcomes in mechanically ventilated patients with traumatic brain injury, a retrospective cohort study.

ABSTRACT:

Purpose

In patients with traumatic brain injury (TBI), adequate oxygenation is crucial to optimize survival and neurological outcome. However, supranormal oxygen partial pressure (PaO₂) only leads to minor increase in cerebral oxygen delivery but can cause numerous pathophysiological disturbances. Therefore, we aimed to study effects of hyperoxia on patient outcome and identify optimum PaO₂ ranges.

Methods

This retrospective, single-center cohort study included TBI patients receiving mechanical ventilation for ≥ 72 h. Time-weighted mean PaO₂ and integrals above thresholds of 80, 100, 120, and 150 mmHg were calculated over periods of 1, 3, 7, and 14 days. The effects on in-hospital mortality and favorable functional outcome defined as Glasgow

SUBMITTER: Lalla LT 

PROVIDER: S-EPMC11761995 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature