Proteinuria and the risk of Incident atrial fibrillation according to glycemic stages: a nationwide population-based cohort study.

ABSTRACT:

Background

Diabetes mellitus (DM) and proteinuria each independently raise the risk of atrial fibrillation (AF). We aimed to investigate the relationship between proteinuria and the risk of incident AF across glycemic stages.

Methods

A cohort of 4,044,524 individuals without prior AF and type 1 DM was selected from the 2009 Korean National Health Insurance Service health checkup data. The individuals were categorized into five glycemic stages: normal, prediabetes, new-onset DM, early DM (< 5 years), and late DM (≥ 5 years). Proteinuria was graded using a urine dipstick test. The development of incident AF was tracked until 2023.

Results

Overall, the cohort (mean age 47 ± 14 years, 44.8% female) showed increasing annual AF incidence rates from 2.05 to 7.22 per 1000 per

SUBMITTER: Yeo M 

PROVIDER: S-EPMC11762047 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature