Unraveling the immunomodulatory and metabolic effects of bioactive glass S53P4 on macrophages in vitro.

ABSTRACT: Macrophage metabolism is closely linked to their phenotype and function, which is why there is growing interest in studying the metabolic reprogramming of macrophages. Bioactive glass (BG) S53P4 is a bioactive material used especially in bone applications. Additionally, BG S53P4 has been shown to affect macrophages, but the mechanisms through which the possible immunomodulatory effects are conveyed remain unclear. According to the results presented here, the lipopolysaccharide (LPS) induced suppression in oxidative phosphorylation is rescued in macrophages cultured with BG S53P4 before the inflammatory stimulus. Additionally, BG S53P4-exposed macrophages expressed lower mRNA levels of inflammatory cytokines Il6 and Il1b, as well as demonstrated decreased activation of inflammatory interfer

SUBMITTER: Kajander K 

PROVIDER: S-EPMC11762225 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature