2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside-stimulated dental pulp stem cells-derived exosomes for wound healing and bone regeneration.

ABSTRACT:

Background/purpose

-2,3,5,4'-tetrahydroxystilbene-2-O-β-D-glucoside (THSG) is a bioactive component in the Chinese herb Polygonum multiflorum, recognized for its anti-inflammatory and lipid-lowering properties. Human dental pulp stem cells (hDPSCs) have excellent capabilities in tooth regeneration, wound healing, and neural repair. The exosomes (Exo) released by hDPSCs contain bioactive molecules that influence cell proliferation, differentiation, and immune responses. Therefore, we aimed to unveil the potential of THSG-Exo and evaluate its regenerative capabilities through the in vitro experiment and rat bone defect model.

Materials and methods

The effects of hDPSC-derived exosomes, with or without THSG treatment, on repair and bone regeneration were evaluated throug

SUBMITTER: Lin TY 

PROVIDER: S-EPMC11762248 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature