Supramolecular discrimination and diagnosis-guided treatment of intracellular bacteria.

ABSTRACT: Pathogenic intracellular bacteria pose a significant threat to global public health due to the barriers presented by host cells hindering the timely detection of hidden bacteria and the effective delivery of therapeutic agents. To address these challenges, we propose a tandem diagnosis-guided treatment paradigm. A supramolecular sensor array is developed for simple, rapid, accurate, and high-throughput identification of intracellular bacteria. This diagnostic approach executes the significant guiding missions of screening a customized host-guest drug delivery system by disclosing the rationale behind the discrimination. We design eight azocalix[4]arenes with differential active targeting, cellular internalization, and hypoxia responsiveness to penetrate cells and interact with bacteria. Lo

SUBMITTER: Tian JH 

PROVIDER: S-EPMC11762306 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature