Inhibitory Effect of <i>Moringa oleifera</i> Seed Extract and Its Behenic Acid Component on <i>Staphylococcus aureus</i> Biofilm Formation.

ABSTRACT: Background/Objectives: Inhibiting biofilm formation without killing cells facilitates the physical removal of contaminating bacteria while minimizing the opportunity for resistant bacteria to emerge. Results: The M. oleifera methanolic seed extract contained 1.48% behenic acid, significantly inhibiting S. aureus biofilm formation. Although behenic acid did not affect cell growth, it inhibited biofilm formation in a concentration-dependent manner, up to 20 mg/L. The cell physiology changes caused by behenic acid are potentially unrelated to biofilm formation inhibition, as no correlation was noted between cell hydrophobicity, polysaccharide production, extracellular DNA production, or protein production and behenic acid concentration. Thus, it was h

SUBMITTER: Kim S 

PROVIDER: S-EPMC11762368 | biostudies-literature | 2024 Dec

REPOSITORIES: biostudies-literature