Clot lysis time and thrombin generation in patients undergoing transcatheter aortic valve implantation.

ABSTRACT:

Background

Aortic valve stenosis (AS) is the most prevalent valvular heart disease and is associated with a significant increase in mortality. AS has been shown to be linked with numerous coagulation system abnormalities, including increased fibrin deposition on the stenotic aortic valves. Transcatheter aortic valve implantation (TAVI) is the primary treatment method for patients at high surgical risk.

Objectives

The aim of the study was to assess the impact of treating severe AS with TAVI on thrombin generation and clot lysis time (CLT).

Methods

We studied 135 symptomatic AS patients recommended for TAVI by the local Heart Team. All measurements were performed before and 5-7 days after TAVI. Alongside clinical assessment and echocardiographic analysis, we assessed cl

SUBMITTER: Siniarski A 

PROVIDER: S-EPMC11762420 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature