Global metabolomic alterations associated with endocrine-disrupting chemicals among pregnant individuals and newborns.

ABSTRACT:

Background

Gestational exposure to non-persistent endocrine-disrupting chemicals (EDCs) may be associated with adverse pregnancy outcomes. While many EDCs affect the endocrine system, their effects on endocrine-related metabolic pathways remain unclear. This study aims to explore the global metabolome changes associated with EDC biomarkers at delivery.

Methods

This study included 75 pregnant individuals who delivered at the University of Cincinnati Hospital from 2014 to 2017. We measured maternal urinary biomarkers of paraben/phenol (12), phthalate (13), and phthalate replacements (4) from the samples collected during the delivery visit. Global serum metabolome profiles were analyzed from maternal blood (n = 72) and newborn (n = 63) cord blood samples collected at delivery.

SUBMITTER: Puvvula J 

PROVIDER: S-EPMC11762426 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature