Metabolic profiles of meconium in preeclamptic and normotensive pregnancies.

ABSTRACT:

Introduction

Preeclampsia (PE) is a common vascular pregnancy disorder affecting maternal and fetal metabolism with severe immediate and long-term consequences in mothers and infants. During pregnancy, metabolites in the maternal circulation pass through the placenta to the fetus. Meconium, a first stool of the neonate, offers a view to maternal and fetoplacental unit metabolism and could add to knowledge on the effects of PE on the fetus and newborn.

Objectives

To compare meconium metabolome of infants from PE and normotensive pregnancies.

Methods

A cohort of preeclamptic parturients and normotensive controls were recruited in Tampere University Hospital during 2019-2022. Meconium was sampled and its metabolome analyzed using liquid chromatography- mass spectrometry

SUBMITTER: Toivonen E 

PROVIDER: S-EPMC11762436 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature