Integrated analysis of chromatin and transcriptomic profiling of the striatum after cerebral hypoperfusion in mice.

ABSTRACT:

Background

Vascular cognitive impairment (VCI) is a significant contributor to dementia, yet the precise mechanisms underlying the cognitive decline associated with chronic cerebral hypoperfusion (CCH) remain unclear. This study investigated the molecular and epigenetic changes in the striatum, a brain region critical for motor function and cognition, following chronic hypoperfusion using a bilateral common carotid artery stenosis (BCAS) model in mice.

Methods

RNA-seq was utilized to identify differentially expressed genes (DEGs) associated with hypoperfusion. In parallel, ATAC-seq was used to assess changes in chromatin accessibility within the striatum, providing insight into the epigenome and potential regulatory mechanisms. The integration of these datasets allowed us to

SUBMITTER: Le S 

PROVIDER: S-EPMC11762485 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature