7,12-Dimethylbenz(a)anthracene as a Model for Ovarian Cancer Induction in Rats.

ABSTRACT: Ovarian cancer has the highest mortality rate of all gynecological cancers. Animal models using 7,12-dimethylbenz(a)anthracene (DMBA) have been developed to investigate the mechanisms of ovarian carcinogenesis. The present study is a systematic review of efforts to establish DMBA as a model for ovarian cancer induction in rat models. A total of 432 studies were retrieved from the Medline/PubMed and Embase databases. The studies using DMBA to induce ovarian cancer with isolated results were included in our analysis, and their data were meta-analyzed. The ROBINS-I tool and a meta-analysis demonstrated a low risk of bias (less than 1%) for increased effectiveness and no bias for mortality. The results were all similar: regardless of the dose, administration route, animal strain, or induction

SUBMITTER: Goncalves ACC 

PROVIDER: S-EPMC11762512 | biostudies-literature | 2025 Jan

REPOSITORIES: biostudies-literature